While it's not really a feud that I'm all that interested in seeing, I do think that it could be a good use of both men at some point in the near future.
Big Show doesn't seem to have anything going on right now. He's out of the WWE Championship picture, though I don't really expect him to stay out of it for too long. I think that WWE could possibly turn it back into a threeway feud with Show, Punk & Cena as a means of keeping them from having too many one on one matches together. After Show's presence there is finished, I could see him moving onto feud with Ryback.
It wouldn't be a classic but at least it would give Ryback real competition against a legit star in the company. Ryback has looked like a beast but, let's face it, there's definitely only so much you can do with putting him in there against jobbers like Jinder Mahal. Also, with the WWE definitely taking the Goldberg route with Ryback, the means there's not going to be a ton of character development going on. This isn't the late 90s and the Goldberg treatment isn't getting eaten up in this day & age as it did back then. Ryback's starting to get a pretty decent response, but he needs something to really get the fans to invest in him on some sort of emotional level beyond "damn, this guy looks like a beast" concept.
Putting him in a feud with Big Show puts him against someone that he's not going to just plow through with little resistance. Portraying Show as a major threat to Ryback could possibly get fans behind him on an emotional level that they haven't yet. Show's a big monster heel and having a big monster heel beating the snot out of you is a good way of getting fans behind you. That's especially true if you take it to the big monster heel courageously.
Personally, when & if he ever makes his return, I think I'd prefer to see Mark Henry feud with Ryback. If they keep Henry with the same sort of persona that he's had over the last year or so, it could be entertaining.