Commercial on ECW tonight just said Jericho/Hardy/Mysterio/Kane in a Fatal Fourway instead of a scramble match. Good. Giving away a Scramble on TV would've been a foolish in my opinion. Sure, its not a massive draw like a Hell in a Cell match or something, but it diminishes it if we see it more often than once a year (which I'm assuming could be the case if they keep using it the way they did last year).
You can write off Kane and Jericho. I just can't see that happening.
So between Mysterio and Hardy, who do they choose? Well, it depends on one thing: is Hardy actually going to leave? If he is, they'll choose him, because they'll want him to put Edge over and get as much use out of Jeff before his contract expires. If Jeff is staying, then I think its safe to say either he or Punk are going to be the babyface in the WHC match at WrestleMania, facing Edge or Jericho. (Personally, I'd like Hardy/Jericho).
WWE has 3 "big matches" to plan out for now. SummerSlam, Survivor Series, and WrestleMania. We've heard rumblings that they want Jericho/Taker for Summerslam, so that would mean either its those two for the title and Edge drops it real soon to take time off, or Jericho/Taker isn't for the title, and we have Edge against Punk, Hardy, or Mysterio. Edge/Mysterio has been done before and never really gets over too well, so its better to use Mysterio right now for a throwaway ppv like Judgment Day, rather than one of the 3 bigger ones.
Ah, I'm rambling. Anyway, yeah, if Hardy is leaving when his contract is up, then its going to be Edge/Hardy without a shadow of a doubt. If Hardy is staying around, it'll be Mysterio/Edge just for a stall until Edge starts up a real feud with Punk or Hardy around Summerslam.