Tyler Mane (WCW, tagged with Kevin Nash as the skyscrapers) as Michael Myers in Rob Zombie's Halloween 1 & 2. Was also Sabretooth in Xmen and Ajax in Troy.
Macho Man Randy Savage in Spider Man.
Jesse The Body Ventura in The Running Man.
But, Andre the Giant in The Princess Bride is far and away the best though.
Rowdy Piper on It's Always Sunny in Philadelphia was funny. Rowdy might be arguably the best actor to come from wrestling (They Live.) Though he's got like 50-100 movies no one has ever heard of.