I don't see any chance of this happening because of what Vince said in his recent podcast interview with Stone Cold Steve Austin. You know, the one where he basically whipped it out and pissed all over 99% of the locker room by trying to lay the fault for whatever shortcomings WWE has on the them rather than taking any share of the blame himself. His comments suggests that the only ones with real star potential that he sees among the active roster are Rollins, Reigns, Ambrose and Bray Wyatt.
For me personally, if given a choice between Ziggler vs. Lesnar, Cena vs. Lesnar, Orton vs. Lesnar or Reigns vs. Lesnar, I'd prefer Ziggler vs. Lesnar. As I've said in a lot of threads, a whole lot of fans are so burned out on Cena & Orton being at the top that it kills some interest in a feud with Lesnar. People are burned out on Cena and there's no real interest in Orton as champ, just look at the reception his last title run received as all the proof you need in that, and Orton is someone who gains nothing by feuding with lesnar. As for Roman Reigns, as has been said countless times in various threads, a lot of people believe he isn't ready. If his rapport with fans and in-ring skills suggest anything, it's that he's probably not ready. He's not bad, but he's not on the level someone being in the main event of WrestleMania should be.
Ziggler vs. Lesnar has a great built in underdog story, we know that Ziggler could help carry Lesnar in a strong performance. However, I don't think Vince sees star potential in Ziggler. Barring Ziggler getting injured or doing something to earn heat, I can see him in the title picture somewhere down the line, maybe even getting a run, but I don't see it anytime in the next 6 to 12 months.