His work vs Horsemen in the 80's is probably his best known stuff. My favorite moment was the World Title Win in 1986 - Remember, the premise that year was The Great American Bash was going to be a month long tour, highlighted by grudge matches and specialty matches like Magnum TA vs Nikita Kolloff in Russian Chain matches or Tully Blanchad vs "Hands Of Stone" Ron Garvin in taped fist matches. Flair, as champ, was to face every legitimate opponent in the company, different wrestler every city, 6 nights a week, all month long, a gruelling test that no champion in any company had ever attempted.
Each week Flair would come out on TV and brag about who he beat last week and who he was going to beat this week and he always promised that NWA owner Jim Crockett JR would be "kissing my ass" when the month was over and he had beaten everyone.
The NWA came up with 13 wrestlers they believed legitimately could draw with Flair, including Rhodes, Magnum, Nikita even though he was a heel like Flair, bothe members of the Rock & Roll Express, Hawk & Animal of the Road Warrior, Garvin, etc. Each got multiple shots at Flair, particulary Ricky Morton who challenged him in a series cage matches.
When Dusty won it was the next to last show, everyone was on pins and needles to see if Flair could survive the challenge, and Rhodes had already failed early in the tour, this was his last shot. Dusty winning, after coming up short vs Ric so many times, with that huge accomplishment just a hair away from Flair's grasp, was momentous. The match itself was one of their best, a brutal bloody cage match with tons of drama (and vulgarity, Flair really got in character when Dusty was on offense and the swear words flew!).
Honestly, I never saw a moment this special, not even Sting's win in 1990, until maybe Sting beat Hogan in 97 or Austin FINALLY won the title vs HBK in 98. Great stuff.