It seems certain to me that Sheamus will win at WrestleMania. Bryan's been built as a squirrely winner and a guy that pulls it out cheaply. Cashed in MITB to win, kept the title out of Show's hands using AJ, snuck out of the cage at the Rumble, and his only elimination in the Chamber came over Santino. Bryan hasn't got any credibility to actually take out Sheamus at WrestleMania. I suppose the match could end in disqualification or countout, but at a Mania that the WWE really needs to come through for them, I doubt they'll pull something like that. More generally, I get the feeling that they're no longer interested in Bryan as a main eventer and that he was mostly a stopgap for a poorly thought out SmackDown roster and a result of Henry's injury. Going even further, I think there's some ambiguity in the results of the other three major matches on the card. Triple H could beat the Undertaker, which would be a pseudo-heel move. Jericho could very well beat Punk. I don't even know which result in Cena/Rock translates to heel/face. The WWE will probably want a clear face winner in this match. Everything adds up - Bryan has next to no chance of walking out of WrestleMania as the WHC.
So, that said, the more interesting question is whether or not Team Ace wins at WrestleMania. It seems the likely move and obviously the most interesting one. The only motivation I could see for the WWE writing off Ace is that they're tired of him on TV, which doesn't make any sense at all. Despite his gimmick being that of a dull blunderer, he's ridiculously interesting as a character and in his actions and has really made Raw a pleasure during his tenure. I suspect that the WWE is well aware of this and intends to place Ace in charge of both shows, although I'm not certain he'll keep both long-term. That's another story. The bottom line is that I do indeed expect Ace to win, although it's not entirely guaranteed, since a heel victory is always a stretch in the WWE.
That said, it seems likely that Christian gets a championship shot against Sheamus, which seems like a good feud to last for a little while. Christian could probably have a very similar feud with Sheamus as he did with Orton - constantly striving for the title, failing, maybe acquiring it briefly by some cheap victory, but losing it back. Meanwhile, they'd probably have phenomenal matches, which I'm game for. I get the feeling Bryan might get shipped to Raw in the draft, which would further support that particularly angle occurring. But to answer the original question, I would consider it very likely that Christian will get his title shot against the World Heavyweight Champion, most likely Sheamus.