Del Rio is an entertaining face champion, and I've enjoyed the feud with Big Show. Booker T recently "suspended" Del Rio, and this new development could add more intrigue to the storyline between both men. I fully expect Del Rio retain the WHC here, because I honestly don't see the point in putting the title on Show so close to Wrestlemania.
There's always a chance Ziggler could cash-in. I could picture a scenario, where Show goes ape-shit after losing the title, beating Del Rio into a pulp. Ziggler takes advantage of the opportunity, and becomes the new WHC.
Either way, we'll see how much faith WWE has in Del Rio at the Chamber pay per view. He could go into Wrestlemania as WHC, and a victory over Show here would be a big step in the right direction for Del Rio's character. Then again, the WHC has been the opening match at the past two Wrestlemanias. Del Rio was apart of one, and the other one was over in eighteen seconds.