There is no way that Mayweather would beat Santana in a wrestling match. Anyone that has boxed before (or follows the sport) should know that you can't put your opponents in headlocks or perform any other wrestling maneuver on them. Beating Mayweather in a wrestling match would be easy. Sure, you could chase him in and out of the ring (much like Brock Lesnar did when he wrestled Rey Mysterio, Jr.), but, if you were smart (like Santana is), you would just let him get counted out or back off until he comes back in. And, when Mayweather goes in for the attack, it's just as easy as chop blocking him, pinning him down, and pummeling him.