Hello my friends I'd like to talk to you about the wonderful world of rectal pharmaceutical products, and ponder on the reason they're not more used.
What are they?
In short, they are pharmaceutical products (i.e. drugs) that are inserted into the rectum via the anus (i.e. sticking drugs up your bum).
What's the point?
There are actually a few benefits to this. Firstly, if you've got a problem in the area, treating it locally has obvious benefits. Secondly, if you can't take drugs orally (and there are many reasons that this may not be possible) this is a viable alternative (it's easier and safer than injections, for example). Thirdly, many drugs can cause stomach ulcers. Bypassing the stomach means no stomach ulcers. And fourthly (and perhaps most importantly) the blood supply in the lower rectum is different to the rest of the gastro intenstinal tract (GIT).
That's so special about the lower rectum?
Simple (or perhaps not), everywhere else in the GIT, the blood goes to the liver (via the hepatic portal vein). As anybody who drinks can tell you, the liver does a lot of metabolising (that is, breaking stuff down into harmless waste products), which reduces the amount of drug you have available for biological use. However, the lower rectum the blood goes straight to the Vena Cava, and from there to the heard and the rest fo the body where it can have its effect. More available drug = more effective.
So why isn't they used more often?
You tell me.
What are they?
In short, they are pharmaceutical products (i.e. drugs) that are inserted into the rectum via the anus (i.e. sticking drugs up your bum).
What's the point?
There are actually a few benefits to this. Firstly, if you've got a problem in the area, treating it locally has obvious benefits. Secondly, if you can't take drugs orally (and there are many reasons that this may not be possible) this is a viable alternative (it's easier and safer than injections, for example). Thirdly, many drugs can cause stomach ulcers. Bypassing the stomach means no stomach ulcers. And fourthly (and perhaps most importantly) the blood supply in the lower rectum is different to the rest of the gastro intenstinal tract (GIT).
That's so special about the lower rectum?
Simple (or perhaps not), everywhere else in the GIT, the blood goes to the liver (via the hepatic portal vein). As anybody who drinks can tell you, the liver does a lot of metabolising (that is, breaking stuff down into harmless waste products), which reduces the amount of drug you have available for biological use. However, the lower rectum the blood goes straight to the Vena Cava, and from there to the heard and the rest fo the body where it can have its effect. More available drug = more effective.
So why isn't they used more often?
You tell me.