While I'm against the Money In The Bank PPV, I can see some benefits and losses for Wrestlemania with removing the match from the card. Firstly, MITB has only been a part of the stable for 5 years at the PPV and prior to that, there were other means and alternatives, but prior to Wrestlemania 21, you had to earn your spot on the card. Here's a list of multi-man matches that have occured (outside of a tag team match) at previous Wrestlemanias:
Wrestlemania 2: 20 Man Battle Royle (won by André), nothing big or special, just a filler.
Wrestlemania 3: Two six person tag team match, again filler.
Wrestlemania 4: Tournament for the title.
Wrestlemania XII: Six person tag, again filler to open the show.
Wrestlemania 13: Four Corners Elimination Tag, Six person tag.
Wrestlemania XIV: 15 Team Battle Royale
Wrestlemania 2000: 23 Man Hardcore Battle Royale, Six person tag, Triangle Ladder Match, the latter being the match that started the fixation to bringing the Multi-man Ladder match into WM.
Wrestlemania X-Seven: Six Person Tag, TLC 2 (enough said), Gimmick Battle Royale, the other two were fillers again.
Wrestlemania X8: Four corner elimination match for the Tag Titles
Wresltmania XX: Fatal Four Tag Title Match (x2) and Cruiserweight Open
As you can see, that half of the Wrestlemanias prior to 21 had filler matches and the only two that stood out to most people are the Triangle Ladder Match and TLC2 which served it's purpose of being an entertaining match with gold at stake. Now what MITB is essentially is nothing more than a filler to get people on the card who have nothing going for them into Wrestlemania but the ability to be specialists with using Ladders and while it's good to speculate over who get a World Title shot, the majority of Wrestlemania was earning your right to be the champion through hard work. Take Savage for example, one of the greatest matches at Wrestlemania 3, the next one he wins the title, the point being is that Savage used Wrestlemania to earn his spot.
While MITB is a great concept, it has gotten stale because we currently assume it's the way to decide a new Main Event Player, while this year has seen the rise of Miz, Morrison, Kofi, Sheamus and Christian, to name a few. And neither had MITB to benefit them, again while I dislike MITB as a PPV, I know that guys like Christian, Kofi and Morrison will serve a better purpose in a singles match with a feud going in than having to use a gimmick match to get them over. Wrestlemania spent the majority of it's first decade without relying on gimmick matches to get itself over and I don't see no harm with going back to basics, it's time Creative stopped being lazy and book the credible guys that been mentioned into matches that we will remember for their ability to work it well, not because it guarantees a new World Champion because the stipulations says so. Also, dropping of the MITB may see the Intercontinental Title get some much deserved love!