Bills actually have an above average defense. Their only problem is their offensive line.
Without an offensive line, you barely have an offense. The Bills better hope Lee and T.O soften the pass rush a bit and help the O-line.
Unless this game doesn't turn out to be a blowout game like most Bills-Pats meetings, I see this being a close game. Then again, this is Randy Moss+Tom Brady I'm talking about here. It will be another blowout(sigh). Patriots win.